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Orexin is a hypothalamic peptide which promotes wakefulness. By blocking orexin
receptors, suvorexant induces sleep. Peaking 2 h after ingestion, it has a
half-life of 12 h and is hepatically metabolized mainly by CYP3A


Belsomra, a new hypnotic, is indicated for the treatment of insomnia characterized
by difficulties with sleep onset and/or sleep maintenance, and is used long-term.


BELSOMRA is contraindicated in patients with narcolepsy.

Side Effects

Belsomra has been found to be generally safe and well-tolerated in patients.
At the recommended therapeutic dose of less than 20 mg, the most common adverse
effect reported has been somnolence.
However, all the patients in this study had received a dose of 30 to 40 mg suvorexant,
which was higher than the current approved dose of 10 mg.[13] Doses higher than 20 mg
have also been reported to be associated with rapid onset of daytime somnolence, motor
impairment, driving impairment, and unconscious night time activity, such as, sleep walking,
suicidal ideation, hypnagogic hallucinations, abnormal dream pattern, and effects resembling
mild cataplexy.[14] It may have a potential additive effect when used with antidepressants
and other drugs with a sedative action.
Other possible side effects include:

Dry mouth
Upper respiratory tract infection
Abnormal dreams

Pregnancy and Lactation

Belsomra should be used during pregnancy only if the possible benefit outweighs
the possible risk to the unborn baby.It is not known if suvorexant crosses into
human milk. Because many medications can cross into human milk and because of
the possibility for serious adverse reactions in nursing infants with use of
this medication, a choice should be made whether to stop nursing or stop the
use of this medication.


When Belsomra interacts with other drugs you get the following reactions

CNS-Active Agents

When Belsomra was co-administered with alcohol, additive psychomotor
impairment was demonstrated. There was no alteration in the pharmacokinetics of suvorexant.

Effects of Other Drugs on Belsomra
Metabolism by CYP3A is the major elimination pathway for suvorexant.

CYP3A Inhibitors

Concomitant use of suvorexant with strong inhibitors of CYP3A (e.g.,
ketoconazole, itraconazole, posaconazole, clarithromycin, nefazodone,
ritonavir, saquinavir, nelfinavir, indinavir, boceprevir, telaprevir,
telithromycin and conivaptan) is not recommended.

The recommended dose of suvorexant is 5 mg in subjects receiving moderate
CYP3A inhibitors (e.g., amprenavir, aprepitant, atazanavir, ciprofloxacin,
diltiazem, erythromycin, fluconazole, fosamprenavir, grapefruit juice,
imatinib, verapamil). The dose can be increased to 10 mg in these patients if necessary for efficacy.

CYP3A Inducers

Suvorexant exposure can be substantially decreased when co-administered
with strong CYP3A inducers (e.g., rifampin, carbamazepine and phenytoin).
The efficacy of suvorexant may be reduced.

Effects of Belsomra on Other Drugs


Concomitant administration of suvorexant with digoxin slightly
increased digoxin levels due to inhibition of intestinal P-gp.
Digoxin concentrations should be monitored when
co-administering suvorexant with digoxin.

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2 reviews for Buy Belsomra Online

  1. BennyBew

    Секрет евреев: Еврейские мужчины лечат простатит за 2-3 недели!
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  2. BennyBew

    Секрет евреев: Еврейские мужчины лечат простатит за 2-3 недели!
    Один раз в жизни! Раз и навсегда! Узнаем как…

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