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Oxycodone, sold under brand names such as Percocet and OxyContin among
many others, is an opioid medication which is used for the relief of
moderate to severe pain. It is usually taken by mouth, and is available
as a single-ingredient medication in immediate release and controlled
release formulations.


Management of pain severe enough to require daily, around-the-clock,
long-term analgesia for which alternative opioid therapies are
inadequate in adults and opioid-tolerant (already on =20mg/day oral
oxycodone or its equivalent) children.


The following conditions are contraindicated with this drug.
Check with your physician if you have any of the following:


systemic mastocytosis,brain tumor,hypothyroidism,Untreated
Decreased Level of Thyroid Hormones
Addison’s Disease,Extreme Loss of Body Water,
Psychosis caused by Sudden Alcohol Withdrawal
psychosis caused by a poisonous agent,Mood Changes,
having thoughts of suicide
addiction to a drug,alcohol intoxication,drug abuse,
Cor Pulmonale,Slow Heartbeat
abnormal heart rhythm,abnormally low blood pressure,
Emphysema,Decreased Lung Function,Stomach or Intestinal
Tract Operation,Ulcerated Colon,Inflammatory Bowel Disease,
constipation,liver problems,Disease of the Gallbladder
Spasm of a Bile Duct Tract,kidney disease with reduction
in kidney function,Narrowing of the Tube that Empties Urine
From the Bladder,Enlarged Prostate,Coma,seizures,Shock,
Cannot Empty Bladder,Weakened Patient
High Pressure Within the Skull,Intense
Abdominal Pain,Morbid Obesity
Asthma That Is Getting Worse.

Side Effects

Oxycodone is not a safer alternative to other opioid analgesics and
it has the same spectrum of adverse effects. Of greatest concern is
the potential for respiratory depression when used at too high a dose
or when combined with other CNS depressants such as benzodiazepines
and alcohol. Combination with other opioids is potentially lethal and
care should be taken to avoid this, especially if people might have
access to a supply of both, e.g. after switching from morphine.

Pregnancy and Lactation

Pregnant women who are dependent on opioids are at high risk of
experiencing complications, generally as a result of:

inadequate antenatal care;
lifestyle factors including smoking, poor nutrition, high
levels of stress and deprivation;
repeated cycles of intoxication and withdrawal which can harm
the foetus or precipitate premature labor or miscarriage.

Breast milk contains only small amounts of methadone and
mothers can be encouraged to breastfeed regardless of methadone
dose provided that they are not using other drugs.
Breastfeeding may reduce the severity of the neonatal withdrawal syndrome.
Women receiving high doses of methadone should be
advised to wean their babies slowly to avoid withdrawal in the infant.


Initiation of CYP3A4 inhibitors (or discontinuation of CYP3A4 inducers) can
result in fatal overdose. May be potentiated by CYP3A4 inhibitors (eg,
macrolides, azole antifungals, protease inhibitors), CYP2D6 inhibitors
(eg, quinidine, fluoxetine); monitor. May be antagonized by CYP3A4 inducers
(eg, rifampin, carbamazepine, phenytoin); monitor. During or within 14
days of MAOIs: not recommended. Avoid mixed agonist/antagonist opioids
(eg, butorphanol, nalbuphine, pentazocine) or partial agonist (eg, buprenorphine);
may reduce effects and precipitate withdrawal symptoms. Increased CNS effects with
concomitant alcohol, benzodiazepines, or other CNS depressants (eg, sedatives,
hypnotics, anxiolytics, neuroleptics, tranquilizers, anesthetics, phenothiazines,
other opioids); consider reducing dose for one or both drugs. May antagonize diuretics.
Increased risk of urinary retention and/or severe constipation with anticholinergics;
monitor. Potentiates muscle relaxants; monitor. Risk of serotonin syndrome with
serotonergic drugs (eg, SSRIs, SNRIs, TCAs, triptans, 5HT3 receptor antagonists,
mirtazapine, trazodone, tramadol, MAOIs, linezolid, IV methylene blue). May increase serum amylase.

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