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Generic Name(S)
oxycodone and acetaminophen




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The combination oxycodone/paracetamol is a combined opioid/non-opioid pain
reliever used to treat moderate to severe acute pain.


PERCOCET (oxycodone hydrochloride and acetaminophen) is indicated for
relief of moderate to moderately severe pain, including conditions
accompanied by fever. PERCOCET is not indicated as an as-needed (prn) analgesic.


• Patients who are hypersensitive to the active substance PERCOCET
(oxycodone hydrochloride and acetaminophen) or other opioid analgesics
or to any ingredient in the formulation.
• Patients with severe hepatic insufficiency or active liver disease.
• In patients with known or suspected mechanical gastrointestinal obstruction
(e.g., bowel obstruction or strictures) or any diseases/conditions that
affect bowel transit (e.g., ileus of any type).
• Patients with suspected surgical abdomen (e.g., acute appendicitis or pancreatitis).
• Patients with mild pain that can be managed with other pain medications.
• Patients with acute or severe bronchial asthma, chronic obstructive airway,
or status asthmaticus.
• Patients with acute respiratory depression, elevated carbon dioxide levels in
the blood and cor pulmonale.
• Patients with acute alcoholism, delirium tremens, and convulsive disorders.
• Patients with severe CNS depression, increased cerebrospinal or intracranial
pressure, and head injury.
• Patients taking monoamine oxidase (MAO) inhibitors (or within 14 days of such therapy)

Side Effects

Adverse effects of PERCOCET (oxycodone hydrochloride and acetaminophen) tablets
are similar to those of other opioid analgesics, and represent an extension
of pharmacological effects of the drug class. The major hazards of opioids
include respiratory and central nervous system depression and to a lesser
degree, circulatory depression, respiratory arrest, shock and cardiac arrest.
The most frequently observed adverse effects of PERCOCET are light-headedness,
dizziness, sedation, nausea and vomiting. These effects seem to be more
prominent in ambulatory than in non-ambulatory patients, and some of these
adverse reactions may be alleviated if the patient lies down.
Other adverse reactions include euphoria, dysphoria, constipation and pruritus.

Pregnancy and Lactation

When taking oxycodone while breastfeeding, the drug can pass through your
breast milk and affect your child. … In fact, the warning label on
Percocet states that the medication should not be taken during
breastfeeding because of possible respiratory depression in infants.


Interaction with Benzodiazepines and Other Central Nervous System (CNS)
-Depressants: Due to additive pharmacologic effect, the concomitant
use of benzodiazepines or other CNS depressants (e.g. other opioids,
sedatives/hypnotics, antidepressants, anxiolytics, tranquilizers,
muscle relaxants, general anesthetics, antipsychotics, phenothiazines,
neuroleptics,antihistamines, antiemetics, and alcohol) and beta-blockers,
increases the risk of respiratory depression, profound sedation, coma, and death.
Reserve concomitant prescribing of these drugs for use in patients for
whom alternative treatment options are inadequate. Limit dosages and
durations to the minimum required. Follow patients closely for signs
of respiratory depression and sedation.
-Psychomotor (Impairment). PERCOCET (oxycodone hydrochloride and acetaminophen)
should not be consumed with alcohol as it may increase the chance of
experiencing dangerous side effects.
-Use with Other Acetaminophen-Containing Products Due to the potential for
acetaminophen hepatotoxicity at doses higher than the maximum daily dose
(4000 mg of acetaminophen per day for adults), PERCOCET should not be used
concomitantly with other acetaminophen-containing products.

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